tubulin
Exemple din articole cu tubulin
- Methodology and Principal Findings We report a natural product Celastrol targets tubulin and facilitates mitotic cell death caused by microtubule drugs.
- Microtubule growth proceeds through the endwise addition of nucleotide-bound tubulin dimers.
- Through our genome-wide gene expression profile analyses of pancreatic ductal adenocarcinoma (PDAC) cells, we identified the overexpression of tubulin tyrosine ligase-like family member 4 (TTLL4) in PDAC cells.
- Proteins of the actin and tubulin superfamilies are major components of the cytoskeleton in all 3 domains of life, archaea, bacteria and eukaryotes [1,2].
- Posttranslational glutamylation of tubulin is present on selected subsets of microtubules in cells.
- Data was obtained from cytotoxicity assays performed with 21 drug molecules from the same family of colchicine compounds and correlate these results with independent tubulin isoform expression measurements for several cancer cell lines.
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